Foundations of Systems Health Course 2

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Modern Systems Biology

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Summary Points of this Lecture

The three key takeaways from this lecture are:
1. The Human Genome Project revealed that we are more than our genes.
2. Biology is an experimental science and has no fundamental ab initio laws.
3. Systems biology aims to build a whole understanding of the human body, bottom’s up, by linking molecular reactions from atom, to molecule, to molecular pathways, to cellular function, to cell, to tissue, to organ, to whole body.

For Medical and Health Practitioners, Use the Concepts of this Lecture to:

1. Become aware of the fallacy of accepting a uni-dimensional approach to addressing your patient’s health concerns.
2. Recognize that just because someone has a particular genetic defect or inclination doesn’t mean they’re predestined to suffer from that disease. Patients can affect their health and their epigenetics though integrating multiple modalities.
2. Medicine must be personalized. No one thing works for everyone.
3. Our health is connected from what we do inside our body plus the events that occur outside our body. So integrate multiple factors in addressing your patient’s issue such as:
—-Food, supplements
—-Changes to their current environment
—-Community interactions
—-Awareness practices


For your homework, you are expected to read the following article:

  1. Ayyadurai, VA Shiva (2012). “What is Systems Biology?”. Chapter from Systems Health: The Revolution in Medicine. VA Shiva Press.

Additional Readings

  1. Ayyadurai, VA Shiva (2010). “Services-Based Systems Architecture for Modeling the Whole Cell: A Distributed Collaborative Engineering Systems Approach”. Commun Med Care Compunetics (2011) 1: 115–168.